Beilstein J. Org. Chem.2011,7, 668–677, doi:10.3762/bjoc.7.79
exhibit a broad spectrum of pharmacological activity such as antifungal, antibacterial, anti-inflammatory and anticancer etc. Triazoles have increased our ability to treat many fungal infections, for example, candidiasis, cryptococcalmeningitis, aspergillosis etc. However, mortality due to these
we are entering a new era of antifungal therapy in which we will continue to be challenged by systemic fungal diseases, the options for treatment will have greatly expanded.
Keywords: antifungal; aspergillosis; candidiasis; cryptococcalmeningitis; triazole; Review
Introduction
The alarming rates
meningitis, cryptococcalmeningitis, systemic and mucosal candidiasis in both normal and immune compromised patients, coccidioidal meningitis, histoplasmosis and infections due to chemotherapy or radiation therapy prior to a bone marrow transplant [44][45][46].
Itraconazole
Itraconazole (10, Figure 9) has